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What is the structure of Akt?
What is the structure of Akt?
CherryBlossomFall
Sun May 26 2024
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6 answers
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Could you please elaborate on the structure of Akt? I'm particularly interested in understanding its key components and how they interact within this protein. Additionally, is there any significance to its structure in terms of its function or regulation within cellular processes? Could you provide some insights into its overall architecture and any notable features that might contribute to its biological activity?
6 answers
alexander_smith_musician
Tue May 28 2024
Akt is a protein that exhibits unique structural and functional features. It is composed of two distinct domains, each playing a crucial role in its biological activity.
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SamsungShineBrightnessRadiance
Tue May 28 2024
The N-terminal region of Akt harbors a lipid-binding PH domain. This domain possesses a specific affinity for two lipid molecules: PI(3,4,5)P3 and PI(3,4)P2.
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Silvia
Mon May 27 2024
The PH domain's lipid-binding capacity is critical for Akt's localization and function within the cell. It allows Akt to interact with specific membrane compartments, where it performs its signaling functions.
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IncheonBeauty
Mon May 27 2024
Moving to the C-terminal portion of Akt, we find the AGC kinase domain. This domain is responsible for Akt's enzymatic activity, specifically its ability to phosphorylate target proteins.
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alexander_jackson_athlete
Mon May 27 2024
A defining characteristic of the AGC kinase domain is the presence of a regulatory tail at its C terminus. This tail serves as a regulatory hub, modulating Akt's activity in response to external stimuli.
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