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Why does CRISPR sometimes fail? It's a question that scientists and researchers often grapple with. CRISPR, a revolutionary gene-editing tool, has the potential to revolutionize medicine, yet its success rate isn't always guaranteed. Could it be due to technical challenges in the delivery of the editing machinery? Or is it the complexity of the human genome that makes precise editing difficult? Perhaps it's the immune system's reaction to the foreign CRISPR components that leads to failure. Understanding the reasons behind CRISPR's failures is crucial for improving its reliability and efficacy in future applications.